Impact of proportionate versus disproportionate mitral regurgitation on acute procedural changes and clinical outcomes following transcatheter mitral valve repair

Abstract Background Transcatheter mitral edge-to-edge repair (TEER) with MitraClip offers a less invasive alternative for patients severe, symptomatic regurgitation (MR) who are considered high risk surgery. However, patient selection TEER remains challenging given the variability in underlying MR pathology and current discordance among studies regarding predictors of procedural efficacy clinical outcomes. Purpose This study aimed to assess acute changes long-term outcomes underwent according proportionality MR, defined as ratio effective regurgitant orifice area (EROA) left ventricular end-diastolic volume (LVEDV). Methods We analyzed at our institution between 2014 2020 available biplane measurement. Relevant comorbidities, demographics, anthropometrics, along pertinent pre- post-procedural echocardiogram measurements, were obtained by review electronic medical record. The EROA LVEDV index was calculated all then stratified quartiles. Patients an EROA/LVEDV lowest quartile having most proportionate those highest disproportionate MR. Baseline post-TEER parameters used longitudinal Results echocardiographic 230 subjects shown table. Following TEER, there larger reduction diameter increased increasingly (p=0.03 p=0.05, respectively). change ejection fraction versus did not significantly differ across groups (p=0.64). Median follow up time 1.7 (0.7–3.5) years; mortality occurred 77 (33.5%) heart failure hospitalizations 20 (8.7%) during up. No significant difference all-cause or identified groups. Conclusions In series, similarly but had severe comorbidities. Post-TEER grade similar Longer-term is needed determine implications. Funding Acknowledgement Type funding sources: None.